Chemokine receptors in drug discovery

Chemokines are a family of small proteins that play an important role in leukocyte trafficking, immunity and inflammation. These chemokines, or cytokines, bind to a group of GPCRs known as the chemokine receptors. The chemokine system is large and complex but despite this difficulty the first small molecule chemokine ligand, a CCR5 antagonist, has reached the market. With a grand total of 19 members, the chemokine receptor family provides significant untapped potential for innovative drug discovery efforts.

Chemokine radioligand displacement assay

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